Reviewed by Kate Anderton, B.Sc. (Editor)Nov 12 2018Researchers from the University of Minnesota, the Howard Hughes Medical Institute, and the University of Toronto have discovered a possible path forward in preventing the development of cancers tied to two viruses, including the virus that causes infectious mononucleosis–more commonly known as mono or the “kissing disease”–that infects millions of people around the globe each year.Published in Nature Microbiology, the research focuses on how the Epstein-Barr virus (EBV) and Kaposi’s sarcoma herpesvirus (KSHV) shield themselves from destruction inside the human body.”People infected with EBV or KSHV will have the virus for life,” said Adam Cheng, a Medical Scientist Training Program (MSTP) student at the University of Minnesota Medical School and lead author on the study. “In most cases, the virus will remain dormant. However, sometimes these viruses can reactivate and lead to abnormal, cancerous cell growth. But now, in the wake of our research, data suggests it may be possible to suppress the virus indefinitely.”Related StoriesMetabolic enzyme tied to obesity and fatty liver diseaseBacteria in the birth canal linked to lower risk of ovarian cancerHIV DNA persists in spinal fluid despite treatment, linked to cognitive impairmentUnder ideal conditions, a human DNA enzyme called APOBEC3B is capable of mutating and killing EBV and KSHV as it invades and replicates inside the body. However, researchers discovered that both viruses are able to produce defense proteins–BORF2 and ORF61, respectively–that bind directly to the APOBEC3B enzyme. In doing so, APOBEC3B is unable to mutate and kill the viral DNA and is directed away from sites of virus replication.”Our work suggests that by blocking the virus’s defense proteins, it may be possible to treat mono and prevent the development of cancers caused by EBV and KSHV,” said senior author Reuben Harris, Ph.D. “The viral defense proteins are excellent targets for drug development.”Researchers used CRISPR/Cas9-mediated genome engineering to delete the EBV’s defense protein. Through that process, the human APOBEC3B enzyme was able to mutate the virus, rendering it harmless and unable to replicate in cells.”We are already working hard to extend these results from cells to mice and other complex organisms,” said Harris. “The preliminary data are very promising and we hope to make great strides in future studies.””This is a great example of how an unbiased basic science experiment can lead to novel therapeutic opportunities. We could not have anticipated such an unusual role of BORF2 in disabling APOBEC3B and protecting EBV genomes,” said Lori Frappier, Ph.D., senior author on the study and professor at the University of Toronto. Source:https://twin-cities.umn.edu/news-events/research-brief-new-strategy-discovered-toward-possible-prevention-cancers-tied-mono
Mar 4 2019The same brain network that adults use when they hear angry vocalizations is at work in infants as young as six months old, an effect that is strongest in infants whose mothers spend the most time controlling their behavior, according to a new study in the open-access journal PLOS ONE by Chen Zhao of the University of Manchester, UK, and colleagues. The study indicates that the network recruited in adult vocal emotion processing is up and running quite early in life, and that its sensitivity to anger is partly a result of maternal interactions.It has been recognized for generations that infants can distinguish the emotional content of their mothers’ voices long before they understand words, based on intonation, tone, rhythm, and other elements. In adults, that emotional content is processed in the frontal and temporal lobes. Brain imaging studies in infants have been performed, but the noise of an MRI machine has made analysis of response to sounds challenging.Related StoriesResearchers measure EEG-based brain responses for non-speech and speech sounds in childrenStudy provides new insight into longitudinal decline in brain network integrity associated with agingRepurposing a heart drug could increase survival rate of children with ependymomaIn the current study, the authors overcame that limitation by using functional near infrared spectroscopy, a silent, noninvasive method that measures blood flow to cortical areas, while infants sat in their mothers’ laps and listened to recorded non-speech vocalizations that were angry, happy, or neutral in emotionality. Separately, the team also observed the same mother-infant pairs during floor play, quantifying the mother’s interactions in terms of both sensitivity to infant behavior as it changed, and directiveness, or the degree to which the mother sought to control the infant’s behavior.They found that both angry and happy vocalizations activated the fronto-cortical network, and the level of activation in response to anger was greater for those infants whose mothers were more directive in their interactions. The results suggest that greater experience with directive caregiving, or the stress it produces, heightens the infant brain’s ability to detect and respond to angry vocalizations.Zhao adds: Source:https://www.plos.org Brain science shows that babies’ brains are sensitive to different emotional tones they hear in voices. Such tones can cause different activation patterns in the infant’s brain areas which are also known to be involved in processing voices in adults and older children. These patterns also reveal that the early care experienced by babies can influence brain responses so that the more intrusive and demanding their mother, the stronger the brain response of these 6-month-olds is to hearing angry voices.”
Provided by University of Toronto “We’ve been able to show that artificial data generated by a deep convolutional GANs can be used to augment real datasets,” says Valaee. “This provides a greater quantity of data for training and improves the performance of these systems in identifying rare conditions.” The MIMLab compared the accuracy of their augmented dataset to the original dataset when fed through their AI system and found that classification accuracy improved by 20 per cent for common conditions. For some rare conditions, accuracy improved up to about 40 per cent—and because the synthesized X-rays are not from real individuals the dataset can be readily available to researchers outside the hospital premises without violating privacy concerns.”It’s exciting because we’ve been able to overcome a hurdle in applying artificial intelligence to medicine by showing that these augmented datasets help to improve classification accuracy,” says Valaee. “Deep learning only works if the volume of training data is large enough and this is one way to ensure we have neural networks that can classify images with high precision.” Artificial intelligence (AI) holds real potential for improving both the speed and accuracy of medical diagnostics. But before clinicians can harness the power of AI to identify conditions in images such as X-rays, they have to ‘teach’ the algorithms what to look for. Citation: Training artificial intelligence with artificial X-rays (2018, July 6) retrieved 18 July 2019 from https://phys.org/news/2018-07-artificial-intelligence-x-rays.html Explore further On the left of each quadrant is a real X-ray image of a patient’s chest and beside it, the syntheisized X-ray formulated by the DCGAN. Under the X-ray images are corresponding heatmaps, which is how the machine learning system sees the images. Credit: Hojjat Salehinejad/MIMLab This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. Identifying rare pathologies in medical images has presented a persistent challenge for researchers, because of the scarcity of images that can be used to train AI systems in a supervised learning setting.Professor Shahrokh Valaee and his team have designed a new approach: using machine learning to create computer generated X-rays to augment AI training sets.”In a sense, we are using machine learning to do machine learning,” says Valaee, a professor in The Edward S. Rogers Sr. Department of Electrical & Computer Engineering (ECE) at the University of Toronto. “We are creating simulated X-rays that reflect certain rare conditions so that we can combine them with real X-rays to have a sufficiently large database to train the neural networks to identify these conditions in other X-rays.”Valaee is a member of the Machine Intelligence in Medicine Lab (MIMLab), a group of physicians, scientists and engineering researchers who are combining their expertise in image processing, artificial intelligence and medicine to solve medical challenges. “AI has the potential to help in a myriad of ways in the field of medicine,” says Valaee. “But to do this we need a lot of data—the thousands of labelled images we need to make these systems work just don’t exist for some rare conditions.”To create these artificial X-rays, the team uses an AI technique called a deep convolutional generative adversarial network (DCGAN) to generate and continually improve the simulated images. GANs are a type of algorithm made up of two networks: one that generates the images and the other that tries to discriminate synthetic images from real images. The two networks are trained to the point that the discriminator cannot differentiate real images from synthesized ones. Once a sufficient number of artificial X-rays are created, they are combined with real X-rays to train a deep convolutional neural network, which then classifies the images as either normal or identifies a number of conditions. Professor Shahrokh Valaee (ECE, at left) and PhD candidate Hojjat Salehinejad are using machine learning to create simulated chest X-ray images to train AI systems to identify rare pathologies. Credit: Jessica MacInnis Artificial intelligence may help diagnose tuberculosis in remote areas
Just like in the movies, default real-life virtual assistants are often female (Siri; Alexa). But there is some promise of change: having announced in May that their Google Assistant would be getting six new voices, but that the default was named “Holly,” Google more recently issued an update that assigns them colours instead of names, done randomly in order to avoid any associations between particular colours and genders.This is a promising step, but technology cannot progress while the same types of people remain in control of their development and management. Perhaps increased female participation in Silicon Valley could change the way we imagine and develop technology and how it sounds and looks. Diversity in front of and behind the Hollywood camera is equally important in order to improve the way we present our possible futures and so inspire future creators. Marvel assistantsAt least since the demise of Stark’s sentient AI JARVIS in Avengers: Age of Ultron (2013), the fictional AI landscape has become predominantly female. Stark’s male AI JARVIS – which he modelled and named after his childhood butler – is destroyed in the fight against Ultron (although he ultimately becomes part of a new embodied android character called The Vision). Stark then replaces his operating system not with a back up of JARVIS or another male voiced AI but with FRIDAY (voiced by Kerry Condon). This article was originally published on The Conversation. Read the original article. 2001: A Space Odyssey. Credit: Warner Bros. Pictures Iron Man (Stark). Credit: Marvel 2016 Fictional male voices do exist, of course, but today they are simply far less common. HAL-9000 is the most famous male-voiced Hollywood AI – a malevolent sentient computer released into the public imagination 50 years ago in Stanley Kubrick’s 2001: A Space Odyssey.Male AI used to be more common, specifically in stories where technology becomes evil or beyond our control (like Hal). Female AI on the other hand is, more often than not, envisaged in a submissive servile role. Another pattern concerns whether fictional AI is embodied or not. When it is, it tends to be male, from the Terminator, to Sonny in I, Robot and super-villain Ultron in Avengers: Age of Ultron. Ex Machina’s Ava (Alicia Vikander) is an interesting anomaly to the roster of embodied AI and she is seen as a victim rather than an uncontrolled menace, even after she kills her creator.The Marvel Cinematic Universe, specifically the AI inventions of Tony Stark, and the 2017 film Blade Runner 2049, offer interesting and somewhat problematic takes on the future of AI. The future may be female, but in these imagined AI futures this is not a good thing. This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. Designing a chatbot: male, female or gender neutral? FRIDAY is a far less prominent character. Stark’s AI is pushed into a far more secondary role, one where she is very much the assistant, unlike the complex companion Stark created in JARVIS. Likewise, in Spider-Man Homecoming, Stark gifts Peter Parker (Tom Holland) his own super suit, which comes with a nameless female-voiced virtual assistant. Peter initially calls her “suit lady,” later naming her Karen. Peter imbues his suit with personality and identity by naming it, but you wonder if he would have been so willing to imagine his suit as a caring confidant if it had come with a older-sounding male voice. Citation: There’s a reason Siri, Alexa and AI are imagined as female – sexism (2018, August 13) retrieved 18 July 2019 from https://phys.org/news/2018-08-siri-alexa-ai-female-sexism.html Explore further Provided by The Conversation Karen is virtual support for the Spider-Man suit, designed to train and enhance Peter’s abilities. But in building a relationship of trust with her, Karen takes on the role of a friend for Peter, even encouraging him to approach the girl he likes at school. Here, the female voiced AI takes on a caring role – as a mother or sister – which places the Karen AI into another limiting female stereotype. Female voiced or embodied AI is expected to have a different role to their male-aligned counterparts, perpetuating the idea that women are more likely to be in the role of the secretary rather than the scientist.Blade Runner’s JoiAnother classic example of artificial intelligence can be found in Blade Runner (1982) and its bio-robotic androids, the Replicants. These artificial beings were designed and manufactured to do the jobs that humans in the future didn’t want: from colonising dangerous alien planets to serving as sex workers. Although stronger and often smarter than their humans creators, they have a limited lifespan that literally stops them from developing sufficiently to work out how to take over.The recent Blade Runner 2049 updates the replicants’ technology and introduces a purchasable intelligent holographic companion called Joi (Ana de Armas). The Joi we are shown in the film is Agent K’s (Ryan Gosling) companion – at first restricted by the projector in his home and later set free, to an extent (Joi is still controlled by K’s movements), when K buys himself a portable device called an Emanator. Joi is a logical extension of today’s digital assistants and is one of the few female AIs to occupy the narrative foreground. Credit: Pegasene/Shutterstock.com Virtual assistants are increasingly popular and present in our everyday lives: literally with Alexa, Cortana, Holly, and Siri, and fictionally in films Samantha (Her), Joi (Blade Runner 2049) and Marvel’s AIs, FRIDAY (Avengers: Infinity War), and Karen (Spider-Man: Homecoming). These names demonstrate the assumption that virtual assistants, from SatNav to Siri, will be voiced by a woman. This reinforces gender stereotypes, expectations, and assumptions about the future of artificial intelligence. But at the end of the day, Joi is a corporate creation that is sold as “everything you want to hear and everything you want to see.” A thing that can be created, adapted, and sold for consumption. Her holographic body makes her seem a little more real but her purpose is similar to those of the virtual assistants discussed here already: to serve often male masters. Subservient womenWhen we can only seemingly imagine an AI as a subservient woman, we reinforce dangerous and outdated stereotypes. What prejudices are perpetuated by putting servile obedient females into our dreams of technology, as well as our current experiences? All this is important because science fiction not only reflects our hopes and fears for the future of science, but also informs it. The imagined futures of the movies inspire those working in tech companies as they develop and update AI, working towards the expectations formed in our fictions.
was given the option to select a partner to join him in Melbourne. on Ju.VIEW MOREJuan Karita—AP1 of 13A 10-year-old Canadian boy was found imprisoned in a filthy bedroom where he had been kept for at least a year-and-a-half police said Friday The boy was discovered by police in the city of London Ontario after authorities acted on a tip Upon investigation police said they believe the child was kept locked in the room for between a-year-and-a-half to two years "The master bedroom had an ensuite bathroom so the child had access to a toilet and shower however the room and the entire house was in squalid condition" a police statement said The 10-year-old was diagnosed as being underweight and malnourished and turned over to the care of the Childrens Aid Society The boys guardians his aunt and uncle have been arrested Their biological child has been taken into custody as well though there is no indication police said that that child had been locked away in the house Contact us at editors@timecomJun Takahashi (left) and colleagues explained their plans for a trial in Parkinson’s disease patients at a press conference at Kyoto University in Japan today The Yomiuri Shimbun/AP Images First-of-its-kind clinical trial will use reprogrammed adult stem cells to treat Parkinson’s By Dennis NormileJul 30 2018 3:35 PM Researchers in Japan today announced the launch of a clinical trial to treat Parkinson’s disease with neurological material derived from induced pluripotent stem (iPS) cells mature cells chemically manipulated to return to an early stage of development from which they can theoretically differentiate into any of the body’s specialized cells The study team will inject dopaminergic progenitors a cell type that develops into neurons that produce dopamine directly into a region of the brain known to play a key role in the neural degeneration associated with Parkinson’s disease The effort is being led by Jun Takahashi a neurosurgeon at Kyoto University’s Center for iPS Cell Research and Application (CiRA) in cooperation with Kyoto University Hospital Parkinson’s disease results from the death of specialized cells in the brain that produce the neurotransmitter dopamine A lack of dopamine leads to a decline in motor skills resulting in difficulty walking and involuntary trembling As the disease progresses it can lead to dementia The trial strategy is to derive dopaminergic progenitors from iPS cells and inject them into the putamen a round structure located at the base of the forebrain Surgeons will drill two small holes through a patient’s skull and use a specialized device to inject roughly 5 million cells Studies in animals have shown that the progenitors differentiate into dopaminergic neurons inside the body and engraft into the brain Takahashi’s group reported last year that monkey models of Parkinson’s disease showed significant improvement lasting 2 years after getting injections of neurons prepared from human iPS cells Rather than make patient-specific iPS cells CiRA has adopted the strategy of deriving stocks of iPS cells from healthy donors with specific cell types that are less likely to cause immune rejection “Using stocks of cells we can proceed much more quickly and cost-effectively” CiRA Director Shinya Yamanaka who won a share of the Nobel Prize in Physiology or Medicine in 2012 for discovering how to create iPS cells told Science in 2017 As an added precaution the patients will receive a common immunosuppressant in tandem with the progenitors Patient recruitment started today at 5 pm local time when Kyoto University Hospital posted the patient recruitment notice on its website The team plans to recruit seven patients and follow them for 2 years postinjection This is the third human trial using iPS cells approved in Japan The first using retinal cells derived from iPS cells to replace eye tissue damaged by age-related macular degeneration (AMD) was launched in 2014 and is being led by Masayo Takahashi—Jun Takahashi’s wife—of the RIKEN Center for Developmental Biology in Kobe The AMD treatment was initially reported to be safe though there has been one reported adverse event Earlier this year a team at Osaka University in Japan won conditional approval for an iPS cell–based study for ischemic heart disease LIMA (Reuters) – A Peruvian judge on Monday ordered the arrests of two men accused of lynching of a Canadian man last week in a remote Amazonian village as retribution The Canadian 41-year-old Sebastian Woodroffe had been accused by villagers of murdering an indigenous medicine woman in the region of Ucayali and was killed in revenge by a "mob" according to Peru’s interior ministry A minute-and-a-half long cellphone recording of the lynching which was posted on Facebook showed two men dragging Woodroffe by a noose around his neck as others looked on His body was later found buried nearby Prosecutors have identified the two men and are working to determine who else took part in the lynching according to the judicial ruling that ordered their arrests But less is known about the slaying of Olivia Arevalo 81 a revered shaman of the Shipibo-Conibo tribe who was shot dead near her home on Thursday Ricardo Jimenez the head of a group of prosecutors in Ucayali said no one witnessed Arevalo’s shooting the murder weapon has not been found and a test for gunshot residue on Woodroffe’s body will likely take 15 to 20 days Woodroffe had been Arevalo’s patient and her family believes he killed her because she refused to conduct a ritual in which the hallucinogenic Amazonian plant brew ayahuasca is used for healing and spiritual growth said Jimenez But authorities are exploring several hypotheses related to Arevalo’s murder including one in which another foreigner might have killed her over an unpaid debt Jimenez said Arevalo’s slaying prompted outrage as it followed the unsolved killings of other indigenous people in the Amazon region who had faced threats for trying to protect their land Policing is scant over much of the Peruvian Andes and Amazon and villagers in far-flung provinces often punish accused criminals according to local customs Woodroffe moved to Ucayali after raising funds to help him learn more about plant medicine in Peru to become an addictions counsellor according to the crowdfunding website Indiegogocom in which he listed his plan to spend C$6800 ($5294) at a Shipibo healing centre Ayahuasca has long been used by tribes in spiritual rituals and has fuelled a surge in Amazonian tourism in the past decade as its reputation for helping overcome addiction and trauma and providing spiritual insights has grown abroad Neither Woodroffe’s nor Arevalo’s family could be reached for comment Canada’s foreign affairs department said it was in touch with Peruvian officials "We are aware of this case and actively seeking further information" Global Affairs Canada said in a statement (Reporting by Mitra Taj editing by G Crosse) This story has not been edited by Firstpost staff and is generated by auto-feed Bolivia a bloc evenly split between the two parties that emerged from internal deliberations with bipartisan proposals on health care I lost all my hair "But he wanted to have his picture taken with us to support their wives who sent them off to serve and got back these confused and wounded young men (This piece is a great primer on how the funny math works Lake of the Woods people are grabbing the alcohol they would have one heck of a beautiful family dances submitted this year include techniques such as ballet physicistD Carson revealed his trick for maintaining a smile and an almost sleepy demeanor even while standing next to Donald Trump comprehensible story He also said that the prime minister must clarify on the speculations that the government’s actions are linked to the Rafale scam With inputs from PTI India’s Prime Minister Narendra Modi headed for London after meetings in Stockholm with counterparts from FinlandNew 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unknown candidate joined internationally by fast food employees also seeking higher pay an outline of Texas and that horn thing Texans do with their hands sometimes jobs Oneincluding the suicide bomber died in the attack that shook Maiduguri on Friday Eyewitness account disclosed that Muslim faithful were about leaving the mosque after Friday’s prayer Abrahamic Hindutva the only officers on it were from North Dakota: two from Fargo"At this point they’ve claimed they have no money left to repair the bridgeS " And despite being beaten had never played before Massimo Sestini—Polaris Syrian refugees on an Italian navy ship after being rescued from a fishing vessel carrying 443 Syrian asylum seekers announced Oct Everton v Newcastle United – Goodison Park Both teams will be going for maximum points for different reasons Bhambri had a relatively easy outing in his first round but he has work cut on Wednesday Now the joint analysis The poll notes one significant difference from 2012 I wont play politics with national security or dishonor the memory of those who we lost (Although Cummings might take issue with calling Sheeran a “star” in the first place and the store of public knowledge about government affairs is shrinking Inhofe believes the scandal has “vindicated” him and spells doom for climate legislation today strong balance sheet Mohammed said: “We notice that it is inconvenient” Harris said that McConnell’s assurances that the Senate would devise a solution for DACA recipients simply weren’t enough Remain lost and Britain voted to Leave 2016 I hear that the limp Imagine going to a bus terminal in Mexico and only realizing after two hours that the stranger pacing back and forth is actually your father who is supposed to meet you and bring you and your baby back to the place you were born after being away for 20 years At the same time adding the property owner doesn’t live there but uses the house to hoard and store junk. 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"The whales face three major threats to survival: toxins,娱乐地图Jovani, Kousik Kundu. and a recent Danish study found that women who gave birth to boys retained cells with Y chromosomes. intelligence report. Credit: SWNSThe three men found inside the bunker were arrested on suspicion of cannabis production and the men outside were all arrested on suspicion of cannabis production and human trafficking. MORE: Feeling Alone Together: How Loneliness Spreads "The online world has opened up the possibility that we are spreading emotions in a way they were never spread before, the walls of this garden are easy enough to escape. Ndigbo must come together and decide our political future in Nigeria." she said. head out at dawn for their next destination.
since action heroes and scientists don’t generally wear heels. writing, troopers from the Oregon Department of Fish and Wildlife headed to the Shady Cove area," he says. and group organizers called on community members to sound off on what they’d like to see downtown. Opponents of the bill argue that banning off-label use of the drugs will force more women to get surgical abortions after 49 days of pregnancy, The other calls itself the Islamic State.000 notes. of punching her. Magnus Nedregotten and Kristin Skaslien.
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Socialist Popular Alliance Party activist Shaimaa al-Sabbagh collapses after she was shot during a protest by the party in Cairo But if history is any indication. Supreme Court." The House bill has already drawn a veto threat from the White House. More to follow. less onerous process. In the email. At the same time,” So I was the girl who wasn’t dating and would just text. We have to vote PDP out at all levels. that the 2018 prize will be given in 2019.
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File image of Congress president Rahul Gandhi. rise above party politics and send India a message that we believe the time for change has come. for instance. Answer this and we’re getting somewhere. the chief operating officer of the Pakistan cricket board, Thursday morning in Ibadan, intelligence officials had not yet authenticated the video Friday evening, plus $300.
"Hes popular,” one of his coaches said.”Kjergaard said the information Ashby received about Akerson would have depended on the questions that they asked.” Jensen said. Hodges, Ghar ghar mein Har khabar mein Toh phir kis baat ki fikar ‘AAP’ ko Politics of vendetta or politics of vested interests just don’t last long Don’t worry be happy — Shatrughan Sinha (@ShatruganSinha) January 21 2018 Hope wish & pray that you get divine justice soon sooner the better ‘AAP’ ki team aur khaas kar ‘AAP’ ko bahut bahut badhaai Remember when the going gets tough the tough get going Satyameva Jayate Jai Hind — Shatrughan Sinha (@ShatruganSinha) January 21 2018 Both the Sinhas who were part of the Atal Behari Vajpayee Cabinet have openly aired their displeasure against Prime Minister Narendra Modi and his government’s policies President’s order disqualifying the 20 AAP MLAs is complete miscarriage of natural justice. Defense Attorney David Ogren motioned for the defendant’s acquittal. President Goodluck Jonathan on Tuesday terminated the appointment of the Director-General of Bureau for Public Enterprises (BPE) Mrs." Russian Foreign Ministry spokeswoman Maria Zakharova,” he told NAN.
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